Human Study of Potential Cure for Huntington’s Disease Using Pig’s Brain Cell Implants

Pig brain cells could be implanted into human brains in USA by the beginning of next year if trials of a pioneering treatment for Huntington’s disease are approved by FDA.

Similar tests on primates have proved “astonishingly successful” in treating the degenerative brain disease, according to researchers who carried out the work at Living Cell Technologies (LCT) in Auckland, New Zealand.

The injection of live animal cells into human brains is likely to raise ethical concerns and fears of pig viruses being transmitted to humans. But researchers say the benefits of a cure outweigh such concerns. “Yes, we have created a chimera, but one that is tolerated and beneficial,” says Bob Elliott, LCT’s medical director.

Huntington’s disease, which affects one in 100,000 people, has a prognosis so terrifying that many people with the gene in their family decline to be tested, preferring to live in ignorance of their fate. Symptoms usually develop between the age of 30 and 50, and include uncontrollable twisting movements, progressing rapidly to disability, dementia and early death.

The pig brain cells used in the treatment are not neurons but come from the lining of a brain structure known as a choroid plexus. They have a nurturing role, mopping up toxins, producing cerebrospinal fluid and secreting a range of hormones and proteins called neurotrophins that are essential for brain cell function and protection. In Huntington’s disease, there is a significant reduction in these chemicals.

“The findings are so remarkable that I am confident that the FDA [US Food and Drug Administration] will fast-track approval of clinical trials for early next year, and we will see product approval in two years,” says Al Vasconcellos, head of LCT’s BioPharma subsidiary in Providence, Rhode Island, which plans to carry out the human trials. “It’s the first time the disease itself can be treated rather than simply the symptoms.”

Source: New Scientist