New gene found to contribute to autoimmune diseases (such as diabetes or lupus)

A new gene suspected to contribute to autoimmune diseases such as type 1 diabetes and lupus - a condition in which the body’s own immune system attacks organs such as the kidneys and skin - has been discovered by Australian National University (ANU) immunologists.

The researchers found that a mutation in the gene, which they have named Roquin, causes the body’s infection fighters - T-cells - to attack their own tissue; the realisation opening the way to explore treatments that target the mutation.

“Roquin stops T-cells from displaying a stimulatory receptor, ICOS, that may cause the cells to attack normal body tissues. Therefore this gene seems critical in protecting us from autoimmunity - but it only takes the mutation of one letter in that gene to cripple its function and lead to autoimmune disease.

Link